Beyond Guidelines: Quantifying CVD, Dementia, and Top-10 Cancers (Safely)

“Standard guidelines are the foundation—but not the ceiling. Many serious conditions brew silently for years. Precision risk assessment helps us find the small subgroup that benefits from deeper evaluation while avoiding scatter-shot testing that creates noise, incidental findings, and missed days of work. The rule is simple: right test, right person, right time.” Dr. Andres Jimenez, Board-Certified in Public Health & Prevention, and Clinical Informatics. Founder & CEO of HealthPrevent360

Guidelines cover essential services, yet many high-burden conditions emerge outside those guardrails or long before symptoms. Quantifying risk for cardiovascular disease, dementia, and multiple cancers can reveal the few employees who need targeted follow-up—if it’s done with discipline.

Principles that protect employees and operations

• Risk-first, not test-first. Start with clinical risk models; escalate only when a threshold is met.

• Additive to primary care. Share concise summaries and next-step options with PCPs; no “diagnosis shopping.”

• Avoid incidental harm. Set strict criteria to limit false alarms, unnecessary scans, and work disruptions.

• Prioritize highest-yield markers. Cardio-metabolic risk, family history, and validated biomarkers guide who benefits from deeper looks.

• Transparent thresholds. Make escalation rules clear to employees and clinicians.

Cancers without a USPSTF-recommended screening account for ~70% of U.S. cancer deaths, underscoring why guideline-only programs miss substantial risk and why disciplined, risk-stratified approaches matter. PMC

A word of caution on “longevity” shopping: Some direct-to-consumer diagnostic offerings target broadly by age and gender, prioritizing volume over appropriateness. That can generate incidental findings, anxiety, and extra time off for follow-up—cost without clarity. Employers should insist on protocols that minimize harm while adding genuine clinical signal.

How HP360 can support you—advanced, but used wisely

We pair prevention science with clear escalation rules—never “more testing for testing’s sake.”

• Quantify risk before recommending advanced diagnostics

• Escalate only when thresholds are met

• Coordinate clean handoffs back to PCPs

• Reduce incidental findings and unnecessary time off

• Provide outcome tracking (engagement, findings, avoided escalations)

Learn About our Employer Prevention Programs

About Dr. Jimenez

Board-certified physician, triple Ivy League–trained innovator leading the nation’s first prevention-only clinic. Dr. Jimenez has built physician-led technology adopted by 3,000+ hospitals and clinics, guided companies through acquisition and IPO, and serves as Assistant Clinical Professor (Environmental & Public Health) at Mount Sinai School of Medicine in NY. At HealthPrevent360, he applies clinical informatics and prevention science to help individuals anticipate risk, prevent and early-detect disease. The clinic’s prevention engine has analyzed hundreds of thousands of clinical pages and supports thousands of patients.